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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Am Chem Soc. 2012 Jan 19;134(4):2100–2110. doi: 10.1021/ja208338j

Figure 4.

Figure 4

The initial steps of collagenolysis. (A) Closed (left) and open/extended (right) forms of FL-MMP-1 in equilibrium. (B) The extended protein binds THP chains 1T-2T at Val23-Leu26 with the HPX domain and the residues around the cleavage site with the CAT domain. The THP is still in a compact conformation. (C) Closed FL-MMP-1 interacting with the released 1T chain (in magenta). (D) After hydrolysis, both peptide fragments (C- and N-terminal) are initially bound to the active site. (E) The C-terminal region of the N-terminal peptide fragment is released.