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. 2012 Feb 28;16(1):37–42. doi: 10.4196/kjpp.2012.16.1.37

Fig. 2.

Fig. 2

Effects of melatonin pretreatment (10-8~10-6 M) on the concentration-response curve for bethanechol (10-9~10-4 M) and effects of 10-7 M melatonin pretreatment on the KCl-induced contractions ([KCl]ECF ; 35 mM, 70 mM, 105 mM and 140 mM) in Sprague-Dawley rat detrusor smooth muscles. (A) Melatonin blocked bethanechol-induced contractions, which were stronger than phenylnephrine contractions, but contraction inhibition effects of the melatonin were not reversed by luzindazole (a melatonin receptor antagonist) (n=12 in each). (B) The melatonin inhibited the contractions at all four conditions of high extracellular KCl concentrations (n=8 in each). Asterisk means p<0.05. Each point represents the mean±standard error of means (SEM).