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. 2012 Feb 28;16(1):37–42. doi: 10.4196/kjpp.2012.16.1.37

Fig. 3.

Fig. 3

Effects of 10-7 M melatonin pretreatment on the frequency-response curve for electrical field stimulation (EFS, 1~40 Hz) and effects of 10-7 M melatonin pretreatment on the concentration-response curve for verapamil relaxation (10-9~10-4 M) in Sprague-Dawley rat detrussor muscles. (A) The melatonin significantly inhibited the EFS-induced contractions (n=8 in each). (B) The basal tension of each strip was adjusted to the optimal isometric tension at which contraction with phenylephrine 10-5 M was maximal. The curve was slightly but significantly inhibited by melatonin pretreatment (n=8 in each). Asterisk means p<0.05. Each point represents the mean±standard error of means (SEM) of the results.