Table 1.
Surface marker expression of myeloid cell subsets.
| Monocytes | Macrophages | Monocytic MDSCs | Granulocytic MDSCs | |
|---|---|---|---|---|
| CDllb | +++ (Leenen et al., 1994; Sunderkotter et al., 2004) | ++ (Leenen et al., 1994; Henderson et al., 2003) | ++ (Youn et al., 2008) | ++ (Youn et al., 2008) |
| CDllc | − (Auffray et al., 2009) | + (Hume, 2008) | + (Umemura et al., 2008) | + (Umemura et al., 2008) |
| F4/80 | + (Henderson et al., 2003; Sunderkotter et al., 2004) | +++ (Leenen et al., 1994; Henderson et al., 2003) | ++ (Movahedi et al., 2008) | − (Youn et al., 2011) |
| Gr-1 | + (Henderson et al., 2003) | + (Henderson et al., 2003) | ++ (Umemura et al., 2008; Youn et al., 2008) | ++ (Umemura et al., 2008; Youn et al., 2008) |
| Ly6C | +++ (Leenen et al., 1994; Sunderkotter et al., 2004) | +/− (Sunderkotter et al., 2004) | +++ (Youn et al., 2008) | + (Youn et al., 2008) |
| Ly6G | − (Auffray et al., 2009) | − (Auffray et al., 2009) | − (Youn et al., 2008) | ++ (Youn et al., 2008) |
| iNOs | +++ (Auffray et al., 2009) | ++ (Fang and Vazquez-Torres, 2002) | +++ (Youn et al., 2008; Gabrilovich and Nagaraj, 2009) | + (Youn et al., 2008; Gabrilovich and Nagaraj, 2009) |
| TNF | +++ (Auffray et al., 2009) | ++ (Rappolee and Werb, 1988) | + (Umemura et al., 2008) | + (Umemura et al., 2008) |
| pDC | Tip-DCs | cDCs CD4− CD8α − | cDCs CD4− CD8α + | |
| CDllb | − (Henderson et al., 2003; Okada et al., 2003) | + (Serbina et al., 2003) | ++ (McLellan et al., 2002; Shortman and Liu, 2002) | − (McLellan et al., 2002; Shortman and Liu, 2002) |
| CDllc | + (Shortman and Liu, 2002; Vremec, 2010) | + (Shortman and Liu, 2002; Serbina et al., 2003) | +++ (McLellan et al., 2002; Shortman and Liu, 2002; Vremec, 2010) | +++ (McLellan et al., 2002; Shortman and Liu, 2002; Vremec, 2010) |
| F4/80 | +/− (Vremec, 2010) | − (Serbina et al., 2003) | + (McLellan et al., 2002; Vremec, 2010) | − (McLellan et al., 2002) |
| Gr-1 | + (Nakano et al., 2001; Shortman and Liu, 2002) | + (Serbina et al., 2003) | − (McLellan et al., 2002) | − (McLellan et al., 2002) |
| Ly6C | + (Okada et al., 2003; Colonna et al., 2004) | − (Serbina et al., 2003) | −/+ (Segura et al., 2009; Davison and King, 2011) | −/+ (Segura et al., 2009; Davison and King, 2011) |
| Ly6G | − (Shortman and Liu, 2002; Okada et al., 2003) | + (Serbina et al., 2003) | − (McLellan et al., 2002) | − (McLellan et al., 2002) |
| iNOs | − (Schleicher et al., 2007) | ++ (Serbina et al., 2003; Auffray et al., 2009) | − (Tam and Wick, 2006) | − (Tam and Wick, 2006) |
| TNF | − (Langhorne et al., 2004) | ++ (Serbina et al., 2003; Auffray et al., 2009) | −/+ (Tam and Wick, 2006) | −/+ (Tam and Wick, 2006) |
| cDCs CD4+ CD8α− | BMDC | dDC | LC | |
| CDllb | ++ (Shortman and Liu, 2002; Vremec, 2010) | + (Lutz et al., 1999) | + (Vremec, 2010) | + (Shortman and Liu, 2002) |
| CDllc | +++ (McLellan et al., 2002; Shortman and Liu, 2002; Vremec, 2010) | + (Lutz et al., 1999) | + (Turley et al., 2010) | + (Turley et al., 2010) |
| F4/80 | + (McLellan et al., 2002; Vremec, 2010) | −/+ (Lutz et al., 1999) | −/+ (Merad et al., 2008) | +/− (Merad et al., 2008; Romani et al., 2010) |
| Gr-1 | + (McLellan et al., 2002) | + (Lutz et al., 1999) | (?) | − (Ginhoux et al., 2006) |
| Ly6C | −/+ (Segura et al., 2009; Davison and King, 2011) | − (Lutz et al., 1999) | (?) | − (Ginhoux et al., 2006) |
| Ly6G | − (McLellan et al., 2002) | −/+ (Lutz et al., 1999) | (?) | − (Ginhoux et al., 2006) |
| iNOs | − (Tam and Wick, 2006) | + (Bonham et al., 1996; Lu et al., 1996) | + (Lowes et al., 2005) | −/+ (Blank et al., 1996; Sugita et al., 2010) |
| TNF | −/+ (Tam and Wick, 2006) | + (Langhorne et al., 2004) | + (Lowes et al., 2005) | + (Larrick et al., 1989) |
(?, controversially discussed; MDSC, myeloid-derived suppressor cell; BMDC, bone marrow-derived dendritic cell; dDC, dermal dendritic cell; LC, Langerhans cell; cDC, conventional dendritic cell; pDC, plasmacytoid dendritic cell; iNOS, inducible nitric oxide synthase; TNF, tumor necrosis factor).