Figure 1.

Allelic expression of ZNF804A at rs12476147 across 10 brain regions, compared with allele ratios in genomic DNA, in eight subjects. Data are represented as the average A/T allele ratio from four measures of each RNA sample and one measure of each genomic DNA sample, corrected by the average allele ratio observed in genomic DNA. The dotted horizontal line represents the average 1:1 genomic allele ratio. A general trend for a difference in allelic expression between brain regions was observed (P = 0.056). Significant (P < 0.05) differences between cDNA and genomic DNA ratios were observed in the temporal cortex (TEMP), parietal cortex (PAR), amygdala (AMYG), hippocampus (HIPP), nucleus accumbens (NAC) and caudate (CAUD). Allele ratios did not significantly differ between genomic DNA and cDNA from the DLPFC, occipital cortex (OCC), cerebellum (CER) or substantia nigra (SN).