Figure 5.

Abnormalities of the SCO in Wnt1-Cre/+; Hdhflox/− mutant mice. (A–F) H&E-stained rostral to caudal coronal sections from newborn littermates WT (A, C, E) and Wnt1-Cre/+; Hdhflox/− (B, D, F) brains, prior to onset of overt hydrocephalus. Note that the rostral portion of the SCO is well developed in the mutant (B), but no structure resembling the SCO is observed in more caudal sections (open arrowheads in D and F). In addition, discontinuities are also observed at distinct levels in the aqueduct (aq), and stenosis of the aqueduct is seen at more caudal level (F). 3v=third ventricle.