Table 3.

Coefficients and p Values from Stable Multivariate Linear Regression Models (3 out of 504) of Log-transformed Nerve Conduction Function Predicted by Hg Biomarker Levels in Urine or Hair, SNP Genotypes and SNP-biomarker Interactions

	SNP Name	db SNP	Base model
			R²	Intercept	Age		Female		BMI		Hand Temperature		Weight		Height		Urine		Hair

				β	β	p	β	p	β	p	β	p	β	p	β	p	β	p	β	p

Log(Ulnar Peak Latency)	Base model ^b	-	0.36	2.12	0.002	0.0001	−0.049	0.0001	−0.001	0.09	−0.031	0.0001					0.006	0.05
Log(Ulnar Peak Latency)	GPX1(C>T) ^a	rs1050450	0.31	2.16	0.002	0.0001	−0.046	0.0001	−0.003	0.02	−0.031	0.0002					0.009	0.07
Log(Ulnar Onset Latency)	Base model ^b	-	0.29	1.92	0.002	0.0011	−0.07	0.0001			−0.03	0.0001							−0.01	0.08
Log(Ulnar Onset Latency)	MT1E 3′UTR(G>T) ^a	rs708274	0.31	2.13	0.002	0.0006	−0.07	0.0001			−0.04	0.0001							−0.019	0.04
Log(Sural Amplitude)	Base model ^b	-	0.25	4.92	−0.02	0.0001							−0.007	0.0001	−0.006	0.03			0.07	0.06
Log(Sural Amplitude)	GCLC 5′ UTR(G>A)	rs17883901	0.34	5.26	−0.01	0.0001							−0.008	0.0003	−0.008	0.01			0.03	0.54

	SNP Name	db SNP
			SNP main effects					SNP-Urine interactions				SNP-Hair interactions
			Major Homozygote	Heterozygote		Minor Homozygote		Urine X Heterozygote		Urine X Minor homozygote		Hair X Heterozygote		Hair X Minor homozygote

			Ref	β	p	β	p	β	p	β	p	β	p	β	p

Log(Ulnar Peak Latency)	Base model ^b	-	-	-	-	-	-	-	-	-	-
Log(Ulnar Peak Latency)	GPX1(C>T)	rs1050450	-	0.017	0.23	-	-	−0.016	*0.05*	-	-
Log(Ulnar Onset Latency)	Base model ^b	-	-	-	-	-	-					-	-	-	-
Log(Ulnar Onset Latency)	MT1E 3′UTR(G>T) ^a	rs708274	-	−0.048	0.005	-	-					0.033	*0.05*	-	-
Log(Sural Amplitude)	Base model ^b	-	-	-	-	-	-					-	-	-	-
Log(Sural Amplitude)	GCLC 5′ UTR(G>A)	rs17883901	-	−0.19	0.09	-	-					0.32	*0.01*	-	-

Pooled heterozygotes and minor homozygotes were compared to major homozygotes

Derived using both 2009 and 2010 data