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. Author manuscript; available in PMC: 2012 Mar 12.
Published in final edited form as: J Am Coll Cardiol. 2009 Sep 1;54(10):877–885. doi: 10.1016/j.jacc.2009.03.080

1. Contribution of Nitric Oxide to Epicardial and Microvascular Coronary Tone.

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The effect of risk factors for coronary atherosclerosis on the change in resting coronary vascular tone with L-NMMA, an antagonist of NO synthesis. The percent change in the coronary vascular resistance, flow, and proximal and distal epicardial diameters with L-NMMA are compared in patients with ≥ 1 risk factor (open circles) and in patients without risk factors (solid circles). Results expressed as mean ± SEM. † P<0.001, and denotes differences in the response to L-NMMA by repeat-measures analysis of variance between patients with and patients without risk factors. *P<0.05, and **P,0.01 denote differences between rest and post-LNMMA measurements in each group. (From reference 31, with permission)