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. Author manuscript; available in PMC: 2012 Mar 12.
Published in final edited form as: J Am Coll Cardiol. 2009 Sep 1;54(10):877–885. doi: 10.1016/j.jacc.2009.03.080

2. Atherosclerosis Risk Factors and Coronary Tone During Endothelial Stimulation.

2

The impact of risk factors for coronary atherosclerosis on the vascular effects of acetylcholine before and after inhibition of nitric oxide synthesis with L-NMMA.. The percent change in the coronary vascular resistance, flow, and proximal and distal epicardial diameters with acetylcholine are compared in patients with ≥ 1 risk factor (open circles) and in patients without risk factors (solid circles) for atherosclerosis. Responses to the peak dose of acetylcholine are compared before and after L-NMMA in the two groups. Results expressed as mean ± SEM. †P<0.03, and denotes differences in the response to acetylcholine between patients with and patients without risk factors. *P<0.05, and **P,0.01 denote differences between control and post-LNMMA measurements in each group. (From reference 31, with permission)