Table 1.
Effect of nitric oxide compounds (10−4 M) on carbachol-induced ciliary muscle contraction in different species.
| Monkey | Bovine (Wiederholt et al., 1994) | Bovine (Kamikawatoko et al., 1998) | Cat (Goh et al., 1995) | |
|---|---|---|---|---|
| SNP (10−4 M) | −77 ± 8§(LONG, n = 9), −84 ± 11§(CIRC) | −45.5§ (n = 8) | −48.6 ± 6.3 (n = 6) | −80 (n = 4) |
| ISDN (10−4 M) | −48 ± 13*(LONG, n = 4), −42 ± 13*(CIRC) | −12 (n = 10) | ||
| L-arg (10−4 M) | −43 ± 12*(LONG, n = 6), −47 ± 16*(CIRC) | |||
| 8-Br cGMP (10−4 M) | −22 ± 9(LONG, n = 6), −34 ± 5§(CIRC) | −13.3§ (n = 8) | −36 ± 3.5 (n = 5) | |
| L-NAME (10−4 M) | +21 ± 8*(LONG, n = 5), −6 ± 15(CIRC) | +8.5 ± 1§ (L-NAG@, 10−4 M, n = 7) |
Data are % change (mean ± S.E.M. (if available)) in carbachol-induced contraction by 10−6 M (monkey, bovine (Wiederholt)); 3 × 10−6 M (cat); 10−5 M (bovine (Kamikawatoko)) carbachol.
*
p < 0.05;
§
p < 0.001.
@
L-NAG (L-nitroarginine) is another inhibitor of nitric oxide synthase. LONG = longitudinal vector; CIRC = circular vector.