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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Exp Eye Res. 2010 Dec 10;93(3):321–327. doi: 10.1016/j.exer.2010.12.003

Table 2.

Effects of nitric oxide compounds on carbachol (CARB)-precontracted monkey ciliary muscle (CM) strips.

Agent, conc (M) Maximum relaxation response % change in CARB ΔForce
Minimum relaxation or enhanced contraction response (agent still present) % change in CARB ΔForce
n
LONG
CIRC
LONG
CIRC
mean sem mean sem mean sem mean sem
SNP
 10−6 −18.78* 6.73 −28.95 12.59 −9.83 7.63 −21.77 13.58 5
 10−5 −53.68* 5.54 −60.79* 9.82 −33.88* 9.19 −40.94* 13.17 8
 10−4 −76.95* 8.22 −83.53* 10.75 −67.29* 7.55 −68.67* 10.79 9
 10−3 −94.64* 7.59 −100.21* 15.47 −85.79* 11.63 −84.75* 19.74 5
ISDN
 10−6 −31.31 11.49 −12.44 14.53 −4.36 4.17 11.15 12.55 4
 10−5 −45.13* 6.70 −27.72 9.61 −7.67 7.62 −3.21 4.17 4
 10−4 −47.80* 13.39 −41.73* 12.68 −13.26 8.65 2.02 3.95 4
L-Arginine
 10−7 −6.34 4.85 −7.95 8.12 24.87* 5.66 25.18* 4.72 4
 10−6 −25.30 10.40 −27.63* 10.04 −1.21 12.24 −0.31 13.49 6
 10−5 −27.86* 10.00 −33.22* 12.91 −0.96 10.48 9.24 10.51 7
 10−4 −42.84* 11.81 −46.82* 16.48 −12.37 7.18 −14.41* 5.59 6
 10−3 −48.04* 9.80 −48.84* 10.08 −19.00 11.91 −11.62 8.83 5
8-Br cGMP
 10−6 −18.33* 5.53 −24.12* 6.16 −1.04 6.17 −4.54 4.63 6
 10−5 −21.95* 4.92 −30.98* 3.60 −8.24 6.01 −15.57 5.11 6
 10−4 −22.27 9.13 −34.45* 4.75 −10.44 6.31 −22.60* 3.07 6
L-NAME
 10−7 −22.86 9.18 −24.90 20.93 10.48 10.48 3.74 11.35 3
 10−6 −8.31 14.41 −32.99* 11.79 9.59 13.26 4.17 12.41 7
 10−5 −15.21 13.01 −38.93* 13.32 15.27 6.87 −3.18 6.61 8
 10−4 −17.76 11.30 −39.72 17.52 21.36* 7.62 −6.50 15.16 5

Data are expressed as the %Δ in the initial CARB contraction force for each vector (longitudinal = LONG; circular = CIRC) versus the concentration of each compound. N is the number of different monkey CMs represented. A given CM may have received more than one concentration of a given agent. Bold values indicate values that are significant. Significantly different from 0.0:

*

p < 0.05, minimum. Initial CARB contraction forces (mean ± S.E.M.) were as follows: SNP, 80.0 ± 9.2 mg LONG, 43.8 ± 6.4 mg CIRC; ISDN, 51.9 ± 20.6 mg LONG, 26.4 ± 9.4 mg CIRC; L-arg, 66.6 ± 9.8 mg LONG, 40.2 ± 6.7 mg CIRC; 8-Br cGMP, 99.8 ± 17.1 mg LONG, 54.4 ± 7.5 mg CIRC; L-NAME, 54.7 ± 10.3 mg LONG, 21.4 ± 2.5 mg CIRC.