Table 1.
Estimated LNG PK parameters.
| PK parameter | Percent change raw scale (95% CI) | LNG GM (90% CI) | LNG + EFV GM (90% CI) | P value | GMR (90% CI) |
|---|---|---|---|---|---|
| AUC12 (ng∗hr/mL) | −56% (−49%, −62%) | 42.9 (38.0, 48.5) | 17.8 (15.5, 20.5) | <0.0001 | 0.42 (0.36, 0.48) |
| Cmax (ng/mL) | −41% (−33%, −50%) | 8.4 (7.6, 9.3) | 4.6 (4.0, 5.4) | <0.0001 | 0.55 (0.49, 0.63) |
| Cmin (ng/mL) | −67% (−59%, −74%) | 2.04 (1.7, 2.3) | 0.6 (0.5, 0.7) | <0.0001 | 0.31 (0.26, 0.36) |
| V/F (L) | 110% (−155%, 176%) | 144 (120, 173) | 256 (217, 301) | 0.0001 | — |
| CL/F (L/hr) | 260% (159%, 364%) | 9.7 (8.0, 11.6) | 32.1 (27.6, 37.3) | <0.0001 | — |
| t1/2 (hr) | −34% (−17%, −55%) | 10.3 (8.1, 13.2) | 5.5 (4.6, 6.7) | 0.0001 | — |