TABLE 3.
Literature search results
| Author (reference), year | Fecal tests | Outcomes reported |
|---|---|---|
|
Randomized controlled trial(s) | ||
| van Rossum et al (19), 2008 | Hemoccult II (Beckman Coulter*) versus OC-Sensor (Eiken†) | Primary outcome for which the trial was powered: CRC detection rates. Other outcomes: specificity, positivity, PPV, participation, AA detection rates |
| van Rossum et al (18), 2009 (Note: this is further analysis of the same data set used in van Rossum et al [19], 2008) | Hemoccult II (Beckman Coulter) versus OC-Sensor (Eiken) | Specificity of the OC-Sensor FIT at different cut-off levels in hemoglobin concentration (ng/mL) |
| Hoffman et al (15), 2010 | Hemoccult II (Beckman Coulter) versus OC-Micro (Eiken) | Primary outcome for which the trial was powered: participation (adherence) |
| Hol et al (17), 2009 | Hemoccult II (Beckman Coulter) versus OC-Sensor Micro (Eiken) | Primary outcome for which the trial was powered: participation Other outcomes: specificity, positivity, CRC and AA detection rates, and PPV |
| Hol et al (16), 2010 (Note: this is further analysis of the same data set used in 2009 Hol [17], 2009) | Hemoccult II (Beckman Coulter) versus OC-Sensor Micro (Eiken) | Specificity, positivity and PPV at different cut-off levels in hemoglobin concentration (ng/mL) |
|
Other studies | ||
| Allison et al (20), 2007 | Hemoccult SENSA (Beckman Coulter) versus FlexSure OBT/Hemoccult ICT (Beckman Coulter) | Primary outcome: advanced neoplasia (defined as CRC or AA) in the distal colon. Other outcomes: specificity, positivity and PPV in testing 3 consecutive bowel movements |
| Grazzini et al (22), 2009 | OC-Hemodia and OC-Sensor Micro (Eiken) | Positivity and PPV comparing a 1 versus 2 day sampling strategy at different cut-off levels in hemoglobin concentration (ng/mL) |
| Park et al (23), 2010 | Hemoccult II (Beckman Coulter) versus OC-Sensa Micro (Eiken) | Primary outcome: detection of advanced neoplasia. Other outcomes: specificity, positivity and sensitivity in testing 3 consecutive bowel movements at different cut-off levels in hemoglobin concentration (ng/mL) |
| Grazzini et al (21), 2010 | OC-Sensor (Eiken) | Effect of seasonal temperature variation on positivity and PPV |
*
Beckman Coulter Inc, USA;
†
Eiken Chemical Company, Ltd, Japan. AA Advanced adenoma; CRC Colorectal cancer; FIT Fecal immunochemical test; FOBT Fecal occult blood test; PPV Positive predictive value