Table 2.
The results of the multiple linear regression analysis for antiretroviral drugs versus MRTD. In the training, dataset only two of the six molecular descriptors showed a statistically significant correlation with therapeutic dose, that is, P[BD] (P = 0.0349) and ASol (P = 0.0140). A multiple regression model equation coefficients are listed with there standard errors, coefficient of determination (R 2 = 0.5970), multiple correlation coefficient (MCC = 0.7727) and residual standard deviation (RSD = 33.89).
| Multiple linear regression | n = 23 | R 2 = 0.5970 | RSD = 33.89 | MCC = 0.7727 |
|---|---|---|---|---|
| independent variables | Coefficient | SE | P-value | R z |
| Constant | −34.3303 | |||
| AlogP | −12.1995 | 6.6976 | 0.0873 | −0.221 |
| ASol | 2.1239 | 0.7697 | 0.0140 | 0.476 |
| logBioHL | 15.9000 | 8.0377 | 0.0654 | −0.071 |
| MW | 0.2159 | 0.1015 | 0.0494 | −0.116 |
| OxidHL | 5.6589 | 2.8478 | 0.0643 | 0.448 |
| P[BD] | 46.5133 | 20.1746 | 0.0349 | 0.427 |
|
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| ANOVA | F-ratio = 3.9507 | P = 0.013 | ||