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The differentiation path of a goblet cell starting from a progenitor and the genes involved in this process. An intestine stem cell becomes an absorptive cell in the absence of the Atoh1 protein but activation of Hes1 or becomes a secretory progenitor cell under the influence of Atoh1 protein with the potential to become either enteroendocrine cells under the direction of neurogenin 3 (Ngn3) or goblet cells under the direction of GFI1 and SPDEF.
