Table III.
Photodegradation Rate and Half-Life (t 1/2) of ATRA in Isopropyl Alcohol (IPA) Solution and ATRA-Loaded NLCs at 25 ± 0.5°C in the Presence of UV A for 6 h (N = 3)
| Formulation | Photodegradation rate (×10−3 h−1) | Half-life (h) |
|---|---|---|
| ATRA in IPA solution | ||
| ATRA 1 mg/g | 92.8 | 7.5 |
| ATRA 3 mg/g | 61.5 | 11.3 |
| ATRA 5 mg/g | 41.2 | 16.8 |
| ATRA in NLCs | ||
| S/CP-ATRA 1 mg/g | 37.6 | 18.4 |
| S/CP-ATRA 3 mg/g | 25.6 | 27.1 |
| M/CP-ATRA 1 mg/g | 36.7 | 18.9 |
| M/CP-ATRA 3 mg/g | 28.4 | 24.4 |
| M/CP-ATRA 5 mg/g | 13.9 | 49.7 |
| S/O/CP-ATRA 1 mg/g | 39.8 | 17.4 |
| S/O/CP-ATRA 3 mg/g | 27.7 | 25.0 |
| S/O/CP-ATRA 5 mg/g | 11.3 | 61.5 |
| S/O/CP-ATRA 7 mg/g | 9.18 | 75.5 |
| S/O/CP-ATRA 9 mg/g | 9.4 | 74.0 |
| M/O/CP-ATRA 1 mg/g | 40.9 | 16.9 |
| M/O/CP-ATRA 3 mg/g | 26.8 | 25.8 |
| M/O/CP-ATRA 5 mg/g | 12.6 | 55.2 |
| M/O/CP-ATRA 7 mg/g | 9.4 | 73.8 |
| M/O/CP-ATRA 9 mg/g | 9.9 | 69.4 |