Table IV.
The Physical (Visual Observation) and Chemical Stability of ATRA-loaded NLCs Following Autoclave and Storage at 4°C for 56 Days
| Formulation | Visual observation | % ATRA content | |||||
|---|---|---|---|---|---|---|---|
| Autoclave | Kept at 4°C for (days) | ||||||
| ATRA crystallization | Phase separation | 14 | 28 | 42 | 56 | ||
| S/CP-ATRA 1 mg/g | – | No | 69.07 | 98.86 | 95.97 | 93.56 | 92.48 |
| S/CP-ATRA 3 mg/g | – | No | 70.24 | 98.76 | 96.18 | 92.55 | 91.27 |
| M/CP-ATRA 1 mg/g | – | No | 70.74 | 99.23 | 96.16 | 94.08 | 92.03 |
| M/CP-ATRA 3 mg/g | – | No | 70.41 | 99.08 | 96.58 | 94.56 | 92.79 |
| M/CP-ATRA 5 mg/g | – | No | 69.45 | 98.89 | 95.03 | 93.17 | 92.01 |
| S/O/CP-ATRA 1 mg/g | – | No | 71.50 | 98.55 | 96.19 | 94.99 | 93.45 |
| S/O/CP-ATRA 3 mg/g | – | No | 70.01 | 99.08 | 97.51 | 95.69 | 92.96 |
| S/O/CP-ATRA 5 mg/g | – | No | 72.16 | 98.89 | 97.23 | 95.93 | 93.96 |
| S/O/CP-ATRA 7 mg/g | + | No | 71.19 | 98.90 | 97.12 | 95.43 | 92.43 |
| S/O/CP-ATRA 9 mg/g | + | No | 68.86 | 98.53 | 96.10 | 95.10 | 92.33 |
| M/O/CP-ATRA 1 mg/g | – | No | 73.77 | 98.97 | 97.04 | 95.04 | 92.70 |
| M/O/CP-ATRA 3 mg/g | – | No | 70.56 | 99.23 | 97.29 | 94.55 | 92.75 |
| M/O/CP-ATRA 5 mg/g | – | No | 73.59 | 99.02 | 96.85 | 95.20 | 92.11 |
| M/O/CP-ATRA 7 mg/g | – | No | 69.28 | 99.05 | 96.28 | 94.98 | 92.83 |
| M/O/CP-ATRA 9 mg/g | + | No | 69.85 | 98.88 | 96.01 | 94.25 | 92.47 |