Table I.
Formulation Characteristics of Loratadine Direct Compression and Liquisolid Tablets
| Formulationa | Drug concentration in liquid medication (% w/w) | Loratadine strength in unit dose (mg) | Propylene glycol (mg) | expL f | Avicel PH 102 (mg) | Aerosil 200 (mg) | Sodium starch glycolate (mg) | Tablet weight (mg) |
|---|---|---|---|---|---|---|---|---|
| F0 | N/A | 10 | N/A | N/A | 100 | 5 | 5 | 120 |
| F1 | 5 | 10 | 190 | 0.287 | 697 | 35 | 49 | 980 |
| F2 | 10 | 10 | 90 | 0.292 | 342.5 | 17.12 | 23.7 | 484 |
| F3 | 20 | 10 | 40 | 0.302 | 165.6 | 8.28 | 11.25 | 235 |
expL f experimental L f
aIn all formulations, the ratio of carrier to coating material is R = 20