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. 2012 Feb 28;2012:924619. doi: 10.1155/2012/924619

Figure 4.

Figure 4

Cytokine expression following HSV-1 infection and treatment with anti-PD-L1 or anti-PD-L2 antibody. C57BL/6 mice were infected with 1,000 PFU HSV-1/cornea. At days 2, 4, and 6 p.i. mice were administered neutralizing antibody to PD-L1, PD-L2, or control IgG. At day 7 p.i. mice were exsanguinated and the TG was processed for suspension array or ELISA. (a) IFN-γ levels. (b) CXCL1 levels. (c) CCL2 levels. (d) CCL5 levels. (e) CXCL10 levels. Cytokine levels are a summary of two to three experiments (n = 6–9). Each bar represents the mean ± SEM expressed in pg/mg of tissue. *P < 0.05 comparing the indicated group to the isotypic control antibody-treated group.