Fig. 3.

JAM-C–deficient mice exhibit electrophysiological and behavioral defects. (A) Isolated sciatic nerves from control littermates (+/−) and JAM-C–KO mice revealed significantly reduced conduction velocities in the KO (*P < 0.05, n = four to eight nerves) and a lag in their CAPs with reduced amplitudes compared with control nerves. (B) JAM-C–KO mice exhibited significantly reduced stride length (*P < 0.05, n = 13 to 18 mice) and grip strength (*P < 0.05, n = 8 to 9 mice). Experiments were performed by a blinded examiner.