Fig. 4.

JAM-C is expressed in human peripheral nerves. Double-staining of human sural nerves for JAM-C (black) and neurofilament (red) obtained from a healthy limb (A) and a patient with a clinical and histopathological diagnosis of chronic inflammatory demyelinating polyneuropathy (B). JAM-C is expressed at paranodal regions (arrows) in healthy nerves, and the number of JAM-C–positive paranodes was significantly reduced in nerves from patients in accordance with the demyelinated state of the fibers (P < 0.01, for six healthy subjects and five patients with neuropathy; the images shown are representative of all samples analyzed). Scale bar, 50 μm.