Table 3. Logistic models for proportion and rate of rare ROHs.
| a) Proportion | b) Rate | |||
| Size | P value | Odds Ratio (95%CI) | P value | Odds Ratio (95%CI) |
| >2 Mb | n.s. | 1.00 (0.86–1.16) | n.s. | 1.04 (0.99–1.10) |
| >3 Mb | 0.02 | 1.22 (1.02–1.45) | 3.08×10−3 | 1.12 (1.04–1.22) |
| >4 Mb | 7.31×10−5 | 1.57 (1.25–1.96) | 0.01 | 1.14 (1.03–1.26) |
| >5 Mb | 8.26×10−6 | 1.77 (1.37–2.26) | 0.01 | 1.17 (1.04–1.31) |
| >6 Mb | 1.19×10−5 | 1.91 (1.42–2.53) | 4.72×10−3 | 1.21 (1.06–1.38) |
| >7 Mb | 3.25×10−7 | 2.39 (1.70–3.31) | 0.01 | 1.22 (1.06–1.42) |
| >8 Mb | 7.73×10−7 | 2.59 (1.76–3.74) | 0.01 | 1.23 (1.05–1.46) |
| >9 Mb | 2.25×10−6 | 2.62 (1.74–3.88) | 0.01 | 1.27 (1.06–1.54) |
| >10 Mb | 1.35×10−3 | 2.09 (1.32–3.25) | n.s. | 1.21 (0.98–1.49) |
a)
Logistic model 4 (adjusted for f, chronological age, and MDS covariates) with phenotype (EOPD case or control, 1 or 0) as dependent variable and proportion of samples with at least one rare ROH of a given minimum size as independent variable.
b)
Logistic model 4 (adjusted for f, chronological age, and MDS covariates) with phenotype (EOPD case or control, 1 or 0) as dependent variable and rate of rare ROHs per person of a given minimum size as independent variable. (Models 1–3 in supplementary material).