Figure 4. Sensitivity of electrophysiological parameters to changes in ionic current properties.

Changes in APD₉₀ (panel A), peak systolic [Ca²⁺]_i (panel B), and [Na⁺]_i (panel C) with changes in I_NaL, I_NaK, I_leak, I_NCX, I_K1 and I_Cab, as labeled next to each curve. Axis x represents the simulation conditions; for “HF Conditions” the remodeling of the basic HF model is considered, for “No Change” the labeled current is unchanged as it is in the GPB model, for “Double Change” the labeled current undergoes a double change with respect to the change exerted in “HF conditions.”