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. 2012 Mar 12;7(3):e32659. doi: 10.1371/journal.pone.0032659

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Trenor et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Simulated APs and ionic currents at a stimulating rate of 1 Hz for HF conditions, 50% inhibition of I_Kr and 30% increase of I_CaL. Panel A shows early afterdepolarizations (EADs; dark line) when I_NaL was doubled and APs with no EADs when I_NaL was normal (light line). The temporal evolutions of I_NaL (panel B), I_rel (panel D), I_CaL (panel C), NCX activity (panel E), and activation gate of I_CaL are also depicted when I_NaL was doubled (dark line) and when I_NaL was normal (light line).