Figure 1. PNNs show considerable, but not exclusive overlap with PV+ cells in the striatum.

(A) Panels show high power micrographs revealing WFA/PNN labeling (left), PV+ immuno-staining (middle), and a merged image of the two (right). Although WFA/PNN and PV+ signals overlapped considerably (arrowheads), both PNNs without PV+ co-labeling (arrows), as well as PV+ cells without PNNs (not visible in this section) were also present. Scale bar: 100 µm. (B) Sample reconstructions of three coronal sections from the anterior striatum (Left to right: rostral, middle, and caudal) showing locations of PV+ cell bodies (red dots) and PNNs (grey rings). Both the degree as well as localization of PNN/PV+ overlap can be seen to vary across the rostro-caudal axis. Right: lateral, up: dorsal. Scale: 500 µm.