Figure 3. Striatal ChABC treatment significantly increases step width and variance in adult mice.

Sample pawprints from ChABC (top) and vehicle (bottom) treated mice (A; see Methods for measurement details). Scale bar: 20 mm. (B) Bar graph showing mean ± standard error of step width for mice receiving either ChABC (ChABC) or vehicle (Saline) injections in bilateral striatum. Enzyme treated animals exhibited significantly increased hind limb gait widths relative to saline controls (Wilcoxon rank sum test; P = 0.0276). *: P<0.05. (C) Variance, the variability in measured step width for a given subject, was also significantly greater in ChABC treated subjects (Wilcoxon rank sum test; P = 0.003). *: P<0.05.