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. 2012 Mar 12;7(3):e33431. doi: 10.1371/journal.pone.0033431

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Muto et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Immunoblots showing the expression of various cell-cycle markers and downstream genes of MSI1 in control and MSI1-KD in U251MG cell lines. MSI1-KD resulted in the up-regulation of Numb, Cyclin B1, and P16, the downregulation of cleaved Notch, and no change in CyclinD1. (B) Immunocytochemistry showed that Cyclin B1 was potently expressed in MSI1-KD cells compared with control cells. (Bar = 200 µm). (C) In PTEN-intact Daoy cells, the immunoblot analysis showed that MSI1-KD led to the up-regulation of PTEN, and down-regulation of cleaved Notch and p-Akt with no change in total Akt level. Error bars represent SEM (*P<0.01).