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. 2012 Mar 12;7(3):e33368. doi: 10.1371/journal.pone.0033368

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A,B) Whole mount Alizarin Red (bone) and Alcian Blue (cartilage) staining of E18.5 Colα1(I) 2.3-Cre;Kif3a^fl/f ^l (A) and control (B) embryos. The size and limb patterning of Colα1(I) 2.3-Cre;Kif3a^fl/fl mice was similar to that of the control mice. (C,D) Movat's pentachrome staining of cross-sections of the radial/ulnar growth plates (cartilage-blue) in E16.5 Colα1(I) 2.3-Cre;Kif3a^fl/f ^l (C) and control (D) mice. (E–J) Cross-sections of E16.5 long bones stained with Picrosirius red (E,F-bright field; G,H-polarized light) to illuminate collagen and Safranin O (I,J) to demarcate cartilage. Both control and Colα1(I) 2.3-Cre;Kif3a^fl/f ^l mice have similar patterns of osteogenic and chondrogenic differentiation. Scale bar: 100 µm.