Figure 4. Axial ulnar loading leads to similar strain at the ulnar midshaft of Colα1(I) 2.3-Cre;Kif3a^fl/fl and control mice.

(A) Image of strain gaging and axial ulnar loading experimental set-up. The right forearms of 16 week old skeletal mature mice were axially loaded for 120 cycles per day for 3 consecutive days with a 2 Hz sine wave using an electromagnetic loading system with feedback control. The left forearms were not loaded and used as non-loaded internal controls. (B) Strain in cortical bone at given mechanical loading levels. Open and closed circles indicate Colα1(I) 2.3-Cre;Kif3a^fl/fl (n = 35) and control (n = 27) mice, respectively. Data presented as mean ± SEM. * p<0.05.