Table 2. Kif3a deletion in osteoblasts and osteocytes has minimal effect on trabecular bone architecture.
| Control (n = 25) | Col2.3-Cre;Kif3a fl/fl (n = 22) | p-value | |
| Proximal Tibia | |||
| BV/TV (%) | 12.6 ± 0.9 | 14.6 ± 1.3 | N.S. |
| Tb.N (1/mm) | 3.75 ± 0.21 | 4.41 ± 0.26 | N.S. |
| Tb.Th (mm) | 0.058 ± 0.002 | 0.055 ± 0.002 | N.S. |
| Tb.Sp (mm) | 0.289 ± 0.019 | 0.246 ± 0.02 | N.S. |
| Conn.D (1/mm3) | 60.4 ± 10.3 | 97.0 ± 16.5 | N.S. |
| Distal Femur | |||
| BV/TV (%) | 15.1 ± 1.0 | 19.0 ± 1.5 | 0.036 |
| Tb.N (1/mm) | 4.31 ± 0.17 | 4.94 ± 0.18 | 0.019 |
| Tb.Th (mm) | 0.057 ± 0.002 | 0.055 ± 0.001 | N.S. |
| Tb.Sp (mm) | 0.238 ± 0.011 | 0.200 ± 0.009 | 0.014 |
| Conn.D (1/mm3) | 104.4 ± 12.7 | 141.1 ± 13.4 | N.S. |
| L5 | |||
| BV/TV (%) | 26.0 ± 0.9 | 24.1 ± 1.0 | N.S. |
| Tb.N (1/mm) | 4.35 ± 0.16 | 4.34 ± 0.16 | N.S. |
| Tb.Th (mm) | 0.64 ± 0.002 | 0.059 ± 0.002 | 0.043 |
| Tb.Sp (mm) | 0.236 ± 0.009 | 0.233 ± 0.009 | N.S. |
| Conn.D (1/mm3) | 119.7 ± 10.5 | 125.2 ± 8.5 | N.S. |
Trabecular bone volume fraction (BV/TV, %), trabecular number (Tb.N, µm−1), trabecular thickness (Tb.Th, µm), trabecular spacing (Tb.Sp, µm), and connectivity density (Conn.D, µm−3) of the proximal tibia, distal femur, and L5 vertebra were measured using microCT. Data presented as mean±SEM. N.S. is not significant (p>0.15).