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. 2012 Mar 12;7(3):e33426. doi: 10.1371/journal.pone.0033426

Figure 2. Tumor injected transgenic MCK-PGC-1α mice maintain upregulation of mtDNA levels and mitochondrial enzymes activity.

Figure 2

A. mtDNA copy number of gastrocnemius and quadriceps of 4-months-old MCK-PGC-1α and wild-type mice, without and with tumor implantation (n = 5/group). B–C. COX and CS enzymatic activity of gastrocnemius (B) and quadriceps (C) muscle homogenates normalized to protein from tumor MCK-PGC-1α and age-matched controls (n = 5/group). D–E. mRNA levels (ΔΔCt) of Ppara, Pparg, Ppard, and Ppargc1b in gastrocnemius (D) and quadriceps (E) normalized to Gapdh at 4-months-old tumor MCK-PGC1–α and aged-matched controls (n = 4/group). Error bars are mean ± SEM.