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. 2012 Mar 12;7(3):e33517. doi: 10.1371/journal.pone.0033517

Table 4. Clinical TNM staging and RECK genotypic frequencies in 135 HCC patients.

Variable rs10814325 rs16932912 rs11788747 rs10972727
TT (N = 21) TC+CC (N = 144) p value GG (N = 64) GA+AA (N = 71) p value AA (N = 83) AG+GG (N = 52) p value TT (N = 76) TA+AA (N = 59) p value
n (%) n (%) n (%) n (%) n (%) n (%) n (%) n (%)
Clinical stage
Stage I/II 12 (57.1%) 72 (63.2%) 0.601 38 (59.4%) 46 (64.8%) 0.517 54 (65.1%) 30 (57.7%) 0.390 49 (64.5%) 35 (59.3%) 0.540
Stage III/IV 9 (49.2%) 42 (36.8%) 26 (40.6%) 25 (35.2%) 29 (34.9%) 22 (42.3%) 27 (35.5%) 24 (40.7%)
Tumor size
≦T2 13 (61.9%) 72 (64.9%) 0.791 41 (64.1%) 46 (64.8%) 0.930 55 (66.3%) 32 (61.5%) 0.577 51 (67.1%) 36 (61.0%) 0.464
>T2 8 (38.1%) 42 (35.1%) 23 (35.9%) 25 (35.2%) 28 (33.7%) 20 (38.5%) 25 (32.9%) 23 (39.0%)
Lymph node metastasis
No 19 (90.5%) 109 (95.6%) 0.298 60 (93.8%) 68 (95.8%) 0.442 79 (95.2%) 49 (94.2%) 0.550 72 (94.7%) 56 (94.9%) 0.639
Yes 2 (9.5%) 5 (4.4%) 4 (6.3%) 3 (4.2%) 4 (4.8%) 3 (5.8%) 4 (5.3%) 3 (5.1%)
Distant metastasis
No 19 (90.5%) 110 (96.5%) 0.235 59 (92.2%) 70 (98.6%) 0.082 83 (100.0%) 46 (88.5%) 0.003* 75 (98.7%) 54 (91.5%) 0.057
Yes 2 (9.5%) 4 (3.5%) 5 (7.8%) 1 (1.4%) 0 (0%) 6 (11.5%) 1 (1.3%) 5 (8.5%)
*

p value<0.05.