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. 2012 Mar 12;7(3):e33546. doi: 10.1371/journal.pone.0033546

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Pathway analysis based on DEGs. (A) 132 genes were found to be upregulated in response to DSS that were subsequently downregulated to control levels after L-Arg supplementation. (B) 27 genes were downregulated in response to DSS and returned to control levels after L-Arg supplementation. (C) Heatmap of the DEGs based on the expression pattern of increased expression after exposure to DSS and decreased expression following L-Arg supplementation. (D) Table showing examples of biologic and signaling pathways, derived from Ingenuity Pathway Analysis, that were found to be affected by these altered gene expression patterns.