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. 2012 Mar 12;7(3):e33546. doi: 10.1371/journal.pone.0033546

Figure 10. Benefits of L-Arg supplementation in DSS-induced colitis are lost in iNOS−/− mice.

Figure 10

7-week-old WT or iNOS−/− C57BL/6 mice received 4% DSS ± 1% L-Arg in the drinking water as in Figures 3– 9. (A) Body weights of the mice were measured daily and are presented as a percentage of their initial body weight. *p<0.05, **p<0.01, ***p<0.001 vs. WT DSS. (B) Survival analysis, as in Figure 3. **p<0.01 vs. WT Ctrl; §§§p<0.001 vs. WT DSS; # p<0.05 vs. iNOS−/− Ctrl; &p<0.05 vs. WT DSS L-Arg. (C) At sacrifice on day 10, colon weight as a percentage of the total body weight was determined as in Figure 3. ***p<0.001 vs. WT Ctrl; §§§p<0.001 vs. WT DSS; # p<0.05, ## p<0.001 vs. iNOS−/− Ctrl; &p<0.05 vs. WT DSS+L-Arg. In (A–C), n = 7–8 for controls, n = 12–22 for treatments.