Table 4.
Risk of histological fibrosis progression by YKL-40 promoter polymorphism at rs4950928
| All patients (n=209) | With fibrosis progression (n=70) | Without fibrosis progression (n=139) | Hazard ratio (95% CI) * | p-value | |
|---|---|---|---|---|---|
| Homozygous major (CC) | 138 (72.3%) | 49 (75.4%) | 89 (70.6%) | 1 Ref | 0.64 |
| Heterozygous (CT) | 50 (26.2%) | 14 (21.5%) | 36 (28.6%) | 0.88 (0.53, 1.48)* | |
| Homozygous minor (TT) | 3 (1.6%) | 2 (3.1%) | 1 (<1%) | ||
| Missing rs4950928 | 18 | 5 | 13 |
Hazard ratio calculated assuming an additive model to compare the 3 genotype groups.