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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Antiviral Res. 2012 Jan 10;93(3):322–329. doi: 10.1016/j.antiviral.2011.12.013

FIG. 2.

FIG. 2

Oseltamivir susceptibility of reference influenza viruses and N6 NA isolates with the I222V NA mutation. Panels A and D show reference human influenza viruses that are known to be sensitive ( Inline graphic) or resistant ( Inline graphic) to oseltamivir. Reference panel control virus A/Fukui/20/2004 (H3N2) was susceptible to both oseltamivir and zanamivir, and A/New Jersey/15/2007 (H1N1) was oseltamivir-resistant but zanamivir-sensitive. Panels B and E show A/Herring Gull/Delaware/665/1988 (H4N6) ( Inline graphic) and A/Herring Gull/Delaware/660/1988 (H13N6) ( Inline graphic) which are both moderately sensitive to oseltamivir. Panel E shows A/Herring Gull/ Delaware/665/1988 (H4N6) ( Inline graphic) and A/Herring Gull/Delaware/660/1988 (H13N6) ( Inline graphic), which both were highly susceptible to zanamivir. A control wild type virus, A/Ruddy Turnstone/ New Jersey /00502/2008 (H4N6) ( Inline graphic) was run as a control (no I222V NA mutation) and is shown in Panels B and E. Panels C and F show the susceptibility of mixed field samples to NAIs oseltamivir and zanamivir. Panels C and F show the mixed field sample ( Inline graphic), which was oseltamivir- and zanamivir-resistant, and A/Pintail Duck/Alberta/66/2005 (H4N6) isolate ( Inline graphic), which was oseltamivir- and zanamivir-sensitive.