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Inhibition of Bcr-Abl in K562 cell lysates by imatinib mesylate. K562 cell lysate was added to serial dilutions (0–100 μM) of imatinib mesylate and incubated in microchannels containing 5% PEG700DA/20% PEG3400 macroporous hydrogel pillars with immobilized GST-Crkl, and detected with anti-phosphotyrosine. Control pillars (No K562) were not exposed to K562 cell extracts or imatinib mesylate. Error bars = SD (n ≥ 6 spots). P < 0.05 between all inhibitor concentrations.
