Table 4.

Risk Factors for Mortality by Cox Proportional Hazards Regression

Variable	Reference Group	Univariate			Multivariate
		Hazard Ratio (95% CI)	p-value	p-value for Variable	Hazard Ratio	p-value	p-value for Variable
Year of ART initiation
1998–2000	2007–2008	3.21 (2.17 – 4.73)	<0.0001	<0.0001	2.17 (0.92 – 5.15)	0.0781	0.1794
2001–2002	2007–2008	1.27 (0.88 – 1.84	0.1942		0.87 (0.47 – 1.62)	0.6634
2003–2004	2007–2008	1.54 (1.30 – 1.82)	<0.0001		0.94 (0.75 – 1.18)	0.6013
2005–2006	2007–2008	1.24 (1.04 – 1.47)	0.0151		1.05 (0.85 – 1.31)	0.6240
ART regimen
PI regimen	NNRTI	0.88 (0.71 – 1.10)	0.2675	0.3164	N/A	N/A	N/A
Other regimen	NNRTI	1.24 (0.81 – 1.92)	0.3259		N/A	N/A	N/A
Site
Barbados	Haiti	0.91 (0.72 – 1.14)	0.4209	<0.0001	1.95 (1.37 – 2.76)	0.0002	<0.0001
Dominican Republic	Haiti	1.40 (1.18 – 1.66)	<0.0001		1.72 (1.34 – 2.21)	<0.0001
Jamaica	Haiti	0.58 (0.42 – 0.80)	0.0010		0.88 (0.52 – 1.47)	0.6183
Martinique	Haiti	0.43 (0.28 – 0.67)	0.0002		1.03 (0.63 – 1.70)	0.8936
Puerto Rico	Haiti	1.59 (1.17 – 2.18)	0.0033		2.25 (1.04 – 4.87)	0.0389
Trinidad	Haiti	0.68 (0.53 – 0.86)	0.0013		0.82 (0.60 – 1.12)	0.2060
Age at ART initiation	Unit = 10 years	1.13 (1.07 – 1.20)	<0.0001		1.19 (1.11 – 1.28)	<0.0001
Gender	Female	1.22 (1.08 – 1.38)	0.0014		1.58 (1.33 – 1.87)	<0.0001
Intravenous drug use	None	1.40 (1.05 – 1.86)	0.0220		1.32 (0.85 – 2.05)	0.2119
Baseline weight	Unit = 10 pounds	0.84 (0.82 – 0.87)	<0.0001		0.85 (0.82 – 0.89)	<0.0001
Baseline hemoglobin	Unit = 1 g/dl	0.82 (0.79 – 0.85)	<0.0001		0.84 (0.80 – 0.88)	<0.0001
Baseline CD4 cell count	Unit = 50 cells/ml	0.88 (0.85 – 0.91)	<0.0001		0.90 (0.86 – 0.93)	<0.0001
TB and ART Co-Treatment	No TB	1.84 (1.53 – 2.21)	<0.0001		1.58 (1.25 – 2.01)	0.0002