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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2011 Dec 1;52(5):923–930. doi: 10.1016/j.yjmcc.2011.11.009

Figure 9. Hypertrophic agonists cause distinct forms of myocyte hypertrophy.

Figure 9

Effects of ISO, PE, TNFα, IGF-1 and serum are plotted against median changes in myocyte phenotype metrics quantified by automated segmentation. Phenotype metrics are cell area, perimeter, elongation, circularity, sarcomeric organization, and cell-cell contact. Hypertrophic agonists and phenotype metrics were grouped by hierarchical clustering. While all agonists increased cell area, they had qualitatively different effects on elongation, sarcomeric organization, and cell-cell contact.