Table 3.
Clinical Factors Associated With Acute CNI-Related Nephrotoxicity and Adjusted For in the SNP Modelsa
| Clinical Factors | Hazard Ratio (95% CI) | p-value |
|---|---|---|
| Tacrolimus Nephrotoxicity | ||
| African American | 0.72 (0.37–1.42) | 0.34 |
| Proximal tacrolimus trough (per 1 ng/mL)b | 1.22 (1.18–1.26) | 1.0×10−31 |
| Antiviral prophylaxis | 0.44 (0.26–0.74) | 0.0020 |
| Prior kidney transplant | 0.38 (0.21–0.69) | 0.0017 |
| Male donor | 0.73 (0.51–1.03) | 0.075 |
| Cyclosporine Nephrotoxicity | ||
| African American | 1.50 (0.68–3.30) | 0.31 |
| Proximal cyclosporine trough (per 100 ng/mL) | 1.59 (1.32–1.93) | 1.8×10−6 |
| Age (per 10 years), linear | 0.97 (0.82–1.14) | 0.67 |
| Age (per 10 years), quadratic | 1.12 (1.02–1.24) | 0.024 |
| Weight at baseline (per 10 kg) | 1.14 (1.01–1.29) | 0.034 |
| Preemptive transplant | 1.58 (0.94–2.65) | 0.083 |
a
All analyses were stratified by center.
b
Proximal CNI trough is a time-varying covariate which is defined as the closest trough concentration obtained prior to any nephrotoxicity event.