Table 4.

SNPs Associated With Acute Cyclosporine Nephrotoxicity in Single SNP Analyses

SNP no.	rs number	Gene Name	Unadjusted Hazard Ratio (95% CI)	p-value	Adjusted Hazard Ratio (95% CI)3	p-value	Allele and MAFd
1	rs2228001	XPC	0.44 (0.30–0.66)	0.00007e	0.41 (0.27–0.63)	0.00004e	C 0.36
2	rs1057910	CYP2C9f	3.20 (1.74–5.89)	0.00019e	3.55 (1.91–6.61)	0.00006e	C 0.05
3	rs1057911	CYP2C9f	3.20 (1.74–5.89)	0.00019e	3.55 (1.91–6.61)	0.00006e	T 0.05
4	rs9332093	CYP2C9f	3.20 (1.74–5.89)	0.00019e	3.55 (1.91–6.61)	0.00006e	G 0.05
5	rs9332098	CYP2C9f	3.20 (1.74–5.89)	0.00019e	3.55 (1.91–6.61)	0.00006e	A 0.05
6	rs712704	PAX4	1.85 (1.29–2.65)	0.00082	2.09 (1.45–3.01)	0.00007e	C 0.20
7	rs1802059	MTRRg	0.41 (0.27–0.62)	0.00003e	0.42 (0.27–0.65)	0.00009e	A 0.34
8	rs2608555	GAN	1.80 (1.25–2.58)	0.00146	2.11 (1.44–3.10)	0.00013e	T 0.24
9	rs1532268	MTRRg	0.42 (0.28–0.64)	0.00006e	0.43 (0.28–0.67)	0.00018e	A 0.34
10	rs1126672	ADH4	1.73 (1.25–2.41)	0.00103	1.85 (1.31–2.63)	0.00055h	T 0.24
11	rs3771342	UGT1A1	1.97 (1.30–2.98)	0.00133	2.09 (1.37–3.19)	0.00062h	A 0.15

^aSNPs are adjusted for race to account for possible population stratification,

^bhazard ratio and 95% confidence interval (CI) of developing toxicity for each risk allele,

^cAnalyses were adjusted for factors significant at 10% level or less, proximal cyclosporine trough, age, age squared, weight, preemptive transplant but always adjusted for race regardless of p-value,

^dallele associated with the hazard ratio and minor allele frequency (MAF),

^esignificant accounting for a FDR of 5%,

^fCYP2C9 SNPs are in LD: r²>0.66 among African Americans, r²=1.0 among non-African American,

^gMTRR SNPs are in LD: r²=0.96 among African Americans, r²=0.99 among non-African American,

^hsignificant accounting for a FDR of 20%,