Table 1.

Effect of DPI and DTI on the growth of sensitive and resistant tumor cell lines in the NCI-60 panel

		GI50		TGI		LC50
		DPI	DTI	DPI	DTI	DPI	DTI
Tumor	Cell Line	Sensitive Cell Lines (nM)
Leukemia	CCRF-CEM	10	2.69 ×103	2.19 ×103	1.20 ×104	6.76 ×104	8.71 ×104
Leukemia	K-562	10	4.16 ×103	4.57 ×103	2.51 ×104	6.46 ×104	9.77 ×104
Leukemia	RPMI-8226	10	0.95 ×103	0.55 ×103	7.53 ×103	3.63 ×104	8.71 ×104
Leukemia	SR	10	2.82 ×103	10.72	5.62 ×103	4.68 × 103	1.91 × 104
NSCLC	NCI-H460	10	0.69 ×103	9.78 ×103	8.91 103	6.76 × 104	7.76 ×104
Colon	HCC-2998	95.5	4.89 ×103	1.23 ×104	1.86 ×104	4.07 ×104	5.13 ×104
CNS	SF-295	95.5	4.79 ×103	4.57 ×103	1.78 ×104	6.76 ×104	5.89 ×104
Melanoma	SK-MEL-5	10	0.912 ×103	3.39 ×103	2.88 ×103	3.24 ×104	7.76 ×104
Renal	CAKI-1	11.5	2.34 ×103	0.45 ×103	6.76 ×103	8.71 ×103	2.95 ×104
		Resistant Cell Lines (nM)
NSCLC	HOP-62	4.79 ×103	1.45 ×104	2.69 ×104	3.31 ×104	8.51 ×104	7.59 ×104
NSCLC	NCI-H226	7.76 ×103	1.51 ×104	3.63 ×104	3.09 ×104	9.12 ×104	6.31×104
Colon	KM12	3.47 ×103	2.95 ×103	2.88 ×104	1.12 ×104	9.12 ×104	8.51 ×104
Renal	SN12C	8.32 ×103	1.41 ×104	3.88 ×104	2.88×104	9.55 ×104	5.89 ×104
Renal	TK-10	5.25 ×103	1.86 ×104	4.57 ×104	4.27 ×104	1 ×105	8.13 ×104
Breast	MDA-MB-231	1.48 ×104	1.62 ×104	4.89 ×104	3.47 ×104	9.33 ×104	7.59 ×104
Breast	HS 578T	3.24 ×103	2.51 ×104	1 ×105	1 ×105	1 ×105	1 ×105