Table 5.

Observed and expected number of mutation by predicted carrier probability under Myriad II: females and males

Carrier prob (%)			Observed				Expected		p value†
	No.	AC Prob	No mutation		Any BRCA		No mutation	Any BRCA
	n	%	n	row%	n	row%	n	N
Female
<5	46	2.9	45	97.8	1	2.2	44.7	1.3	1.000
5 to <10	161	6.7	148	91.9	13	8.1	150.2	10.8	0.671
10 to <20	45	15.8	35	77.8	10	22.2	37.9	7.1	0.419
20 to <40	27	33.8	16	59.3	11	40.7	17.9	9.1	0.573
≥40	6	58.4	3	50.0	3	50.0	2.5	3.5	1.000
Total	285	11.2	247	86.7	38	13.3	253.1	31.9	0.444
Male
<5	1	2.8	1	100	0	0	0.97	0.03	1.000
5 to <10	0	0.0	0	0	0	0	0	0	–
10 to <20	21	12.8	18	85.7	3	14.3	18.3	2.7	1.000
20 to <40	2	21.8	1	50	1	50	1.6	0.4	1.000
≥40	1	41.9	0	0	1	100	0.6	0.4	1.000
Total	25	14.3	20	80	5	20	21.4	3.6	1.000

Carrier Prob (%) range of carrier probability for each proband data; No. number of probands in the corresponding range; AC Prob (%) average carrier probability in the corresponding range

^†Pearson χ² goodness of fit test