Table 6.

Observed and expected number of mutation by predicted carrier probability under BOADICEA: females and males

Carrier prob (%)			Observed						Expected			p value†
	No.	AC Prob	No mutation		BRCA1		BRCA2		No mutation	BRCA1	BRCA2
	n	%	n	row%	n	row%	n	row%	n	n	n
Female
<5	171	2.1	163	95.3	2	1.2	6	3.5	167.4	0.9	2.7	0.424
5 to <10	35	6.9	31	88.6	1	2.9	3	8.6	32.6	0.6	1.8	0.809
10 to <20	42	14.0	32	76.2	4	9.5	6	14.3	36.1	2.4	3.5	0.53
20 to <40	14	27.3	9	64.3	2	14.3	3	21.4	10.2	1.5	2.3	0.898
≥40	23	69.9	12	52.2	6	26.1	5	21.7	6.9	8.8	7.3	0.326
Total	285	11.1	247	86.7	15	5.3	23	8.1	253.4	12.5	19.2	0.723
Male
<5	6	1.2	6	100.0	0	0.0	0	0.0	5.9	0.0	0.1	1.000
5 to <10	11	7.9	9	81.8	0	0.0	2	18.2	10.1	0.0	0.9	1.000
10 to <20	6	13.9	5	83.3	0	0.0	1	16.7	5.2	0.0	0.8	1.000
20 to <40	1	34.2	0	0.0	0	0.0	1	100.0	0.7	0.0	0.3	1.000
≥40	1	96.5	0	0.0	0	0.0	1	100.0	0.04	0.0	0.97	1.000
Total	25	12.3	20	80.0	0	0.0	5	20.0	21.9	0.0	3.1	0.702

Carrier Prob (%) range of carrier probability for each proband data; No. number of probands in the corresponding range; AC Prob (%) average carrier probability in the corresponding range

^†Pearson χ² goodness of fit test