Fig. 5.
Effect of standard antipsychotic drugs, haloperidol and clozapine, on the amphetamine-induced hyperactivity in mice (a). Clozapine and haloperidol were given 30 min before the amphetamine administration. LSP1-2111 dose dependently abolished amphetamine hyperlocomotion when administered 45 min before amphetamine (b). LY341495 abolished the effect of the highest dose of LSP1-2111 (5 mg kg−1) when given 15 min prior LSP1-2111 (c). Locomotor activity was monitored every 10 min over an 80-min session immediately following an injection of psychostimulant agent. The data are presented as means ± SEM and analyzed by repeated measure ANOVA (inset the total activity of mice within the 80 min session was analyzed by one-way ANOVA [a, b] or two-way ANOVA [c]) # p < 0.001 vs. control group and *** p < 0.001, **p < 0.01, and *p < 0.05 vs. amphetamine-treated group