Figure 1.
Primary and secondary structures of the substrate/ribozyme (S/R) pairs characterized here. (A) Parental VS ribozyme (R0) and substrate (S0). Substrate recognition involves a kissing-loop interaction between residues 630-632 of S0 and 697–699 of R0. The arrowhead points to the cleavage site and the dashed box encloses the region under investigation. (B) Variant S/R pairs. Only the mutated regions are shown along with the nomenclature of the mutated substrates and ribozymes.