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. 2011 Nov 21;40(5):2247–2257. doi: 10.1093/nar/gkr1052

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Regions of the ribosomal exit tunnel essential for stalling. (A) Lateral vision of the 70S ribosome of E. coli (20). (B) Sagittal plane section of the 70S ribosome (20). (C) Visual amplification of the PTC and the first part of the exit tunnel. Nucleotides in orange constitute the PTC region; these nucleotides are involved in the peptidyl transferase and hydrolysis of peptidyl-tRNAs during translation (38). Nucleotides in red are essential for stalling induced by the nascent peptides ErmCL and SecM (13,24). Nucleotides in pink and the amino acid residue K90 of the ribosomal protein L22 are essential for stalling induced by SecM and TnaC (13,19). Nucleotides in cyan connect the nucleotides U2585 and U2609. White arrow indicates possible structural relay from the exit tunnel to the PTC produced by the TnaC nascent peptide.