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. 2011 Nov 8;40(5):2065–2075. doi: 10.1093/nar/gkr905

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Contribution of individual BER enzymes to survival after exposure to oxidative stress. Mutant strains of all identified and putative BER enzymes in MC58 N. meningitidis were constructed and tested for survival under conditions of oxidative stress. Survival was calculated by comparing the number of bacteria recovered after treatment with 0.4 mM H₂O₂, or phosphate buffered saline, and shown as the percentage survival relative to the wild-type strain, MC58. Data shown are the mean of a minimum of three repeats with error bars to indicate the SD. Strains tested were deletions of: formamidopyrimidine DNA glycosylase (ΔmutM); adenine DNA glycosylase (ΔmutY); 8-oxoG nucleotide triphosphatase (ΔmutT); endonuclease III (Δnth); 3-methyladenine DNA glycosylase (Δtag); uracil N glycosylase (Δung); Neisserial AP endonuclease (Δnape); Neisserial exonuclease (Δnexo).