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. 2011 Nov 10;40(5):2168–2180. doi: 10.1093/nar/gkr926

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Self-assembly equilibrium reactions for the tectoRNA systems reported. (A) TectoRNA heterodimer (HD) system: a HD-forming module (M_HD) assembles with a probe (P) through GNRA/receptor interactions to form a heterodimer (P × M_HD). This system is used as control. (B) 5′ PK attenuator system: the tectoRNA attenuator (M_AT), consisting of a HD-forming module linked to a PK-forming module, can assemble with a probe (P) through its HD-forming module (equilibrium on the right) to form the heterodimer (P × M_AT). Attenuation of inter-molecular self-assembly between the tectoRNA attenuator and the probe occurs when the PK-forming module interacts with the 5′ side (in green) of the receptor of the HD-forming module to form a 5′ PK (equilibrium reaction between brackets). Interacting receptor (R) and loop (L) motifs as well as pseudoknot (PK) are indicated. Equilibrium reactions and 3D stereo view for the 3′ PK attenuator system are provided Supplementary Figure S1.