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Biological activity and DNA-binding of β-substituted hairpin polyamides. Cytotoxicity analyses were conducted 96 h following polyamide treatment in the A549 lung carcinoma cell line. IC50 values representing the mean of three biological replicates. ΔTm denotes the shift in melting temperature following polyamide treatment for the 5′-WGWWCW-3′ duplex DNA sequence shown.
